| 发明名称 |
Isoxazoline and isoxazole fibrinogen receptor antagonists |
| 摘要 |
This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
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| 申请公布号 |
US5849736(A) |
申请公布日期 |
1998.12.15 |
| 申请号 |
US19950455436 |
申请日期 |
1995.05.31 |
| 申请人 |
THE DUPONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
WITYAK, JOHN;XUE, CHU-BIAO;SIELECKI-DZURDZ, THAIS MOTRIA;OLSON, RICHARD ERIC;DEGRADO, WILLIAM FRANK;CAIN, GARY AVONN;BATT, DOUGLAS GUY;PINTO, DONALD;HUSSAIN, MUNIR ALWAN;MOUSA, SHAKER AHMED |
| 分类号 |
A61K31/42;A61K31/423;A61K31/425;A61K31/435;A61K31/44;A61K31/445;A61K31/47;A61K31/495;A61K31/496;A61K31/50;A61K31/505;A61K31/535;A61K31/5377;A61K31/55;A61K31/66;A61K31/665;A61K45/00;A61P1/00;A61P3/08;A61P3/10;A61P7/02;A61P7/04;A61P9/08;A61P9/10;A61P11/00;A61P17/00;A61P19/10;A61P27/02;A61P27/14;A61P29/00;A61P31/04;A61P35/00;A61P37/00;A61P37/08;A61P43/00;C07D261/04;C07D261/06;C07D261/10;C07D261/12;C07D261/18;C07D261/20;C07D413/04;C07D413/06;C07D413/12;C07D413/14;C07D417/12;C07D498/10;C07F7/10;C07F9/653;C07F9/6571;(IPC1-7):C07D261/02;C07D217/00;A61K31/54 |
主分类号 |
A61K31/42 |
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