发明名称 |
HUMAN PLURIPOTENT HEMATOPOIETIC COLONY STIMULATING FACTOR, METHOD OF PRODUCTION AND USE |
摘要 |
Highly purified pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparent homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5 X 10 8 U/mg protein.
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申请公布号 |
CA1340266(C) |
申请公布日期 |
1998.12.15 |
申请号 |
CA19860505397 |
申请日期 |
1986.03.27 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
WELTE, KARL;PLATZER, ERICH;GABRILOVE, JANICE L.;MERTELSMANN, ROLAND;MOORE, MALCOLM A. S. |
分类号 |
C07K14/53;A61K38/19;C12N5/08;C12P21/02;(IPC1-7):C07K14/53 |
主分类号 |
C07K14/53 |
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