| 摘要 |
<p>The present invention relates to a recombinant Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine comprising PRRSV structural genes linked to a heterologous polymerase gene and the method for constructing the recombinant virus. Specifically, the recombinant virus comprises the genes encoding open reading frames 1a and 1b from Equine Arteritis Virus (EAV) and the genes encoding open reading frames 2 through 7 from PRRSV. The invention is useful for producing PRRSV vaccines that are resistant to mutaions that currently occur during propagation of PRRSV for vaccines. Furthermore, the invention provides a means for distinguishing swine vaccinated with the aforementioned invention from swine naturally infected with PRRSV.</p> |
