| 摘要 |
<p>The present invention relates to hsPLA2 gr II and to specific hsPLA2 gr II peptides exhibiting an anticoagulant effect, to antibodies which are directed against said peptides and to pharmaceutical compositions comprising said peptides or antibodies. The present invention further relates to methods of regulating the coagulant effect and to methods of treating or preventing thrombus formation and limiting platelet activation in vivo in human or in animal comprising the step of administering an effective amount of said peptides. The present invention further relates to methods of screening new pharmaceutical compounds which may be used for the prevention or treatment of hemostatic disorders and to kits for the determination of hemostatic disorders.</p> |
