| 摘要 |
The invention relates to methods for mono and 1,7-bis-N-.beta.-hydroxyalkylation of cyclene, to corresponding mono and 1,7-bis-N-.beta.-hydroxyalkyl-1,4, 7,10-tetraazacyclododecane-Li salt complexes as intermediate products in said method and to the use of N-(6-hydroxy-2,2- dimethyl-1,3-dioxepane-5-yl) -1,4,7,10-tetraazacyclododecane-LiCl complex in the production of gadobutrol ¢Gd complexes of N-(1-hydroxy-methyl-2,3- dihydroxypropyl)-1,4,7-tricaboxymethyl-1, 4,7,10-tetraazacyclododecane!.
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