发明名称 |
RADIOPROTECTANT FOR PEPTIDES LABELED WITH RADIOISOTOPE |
摘要 |
A method of ameliorating degradation of radiolabeled peptides, especially radiolabeled proteins such as antibodies, by including povidone, also widely known as polyvinylpyrrolidone or PVP, as a radioprotectant in a composition containing a radiolabeled peptide is described. A radioprotectant composition and a stable peptide-radioisotope composition having povidone are also described. Ascorbic acid or other secondary stabilizers may also be added to the compositions to further enhance radioprotection. |
申请公布号 |
CA2290987(A1) |
申请公布日期 |
1998.12.10 |
申请号 |
CA19982290987 |
申请日期 |
1998.06.03 |
申请人 |
COULTER PHARMACEUTICAL, INC. |
发明人 |
BUCKLEY, MICHAEL J.;CHAN, ALBERT S. K.;SHOCHAT, DAN;COLCHER, DAVID |
分类号 |
A61K51/00;A61K39/395;A61K51/08;A61K51/12;A61P37/00;(IPC1-7):A61K51/08 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|