发明名称 |
ALKALOID COMPOUNDS, METHOD OF THEIR PREPARING, PHARMACEUTICAL COMPOSITION |
摘要 |
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to new alkaloids from Mappia foetida (foetidines 1 and 2) of the general formula (I) <EMI ID=0.184 HE=81 WI=105 TI=CHI> where R is H (1) or R is OCH<SB>3</SB> (2). These water-soluble alkaloids are precursors of camptothecin and 9-methoxycamptothecin which are present in all parts of plant being the latter are water-insoluble. New water-soluble alkaloids can be used for parenteral administration that ensures to avoid the use of toxic vehicles and unwanted chemical derivatives. Foetidines are obtained by extraction of different parts of plant Mappia foetida with aliphatic low-molecular alcohols or ketones. New water-soluble alkaloids show anticancer and antiviral properties. EFFECT: improved method of preparing. 8 cl, 2 ex
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申请公布号 |
RU2123005(C1) |
申请公布日期 |
1998.12.10 |
申请号 |
RU19940026100 |
申请日期 |
1994.07.13 |
申请人 |
INDENA S.P.A. |
发明人 |
EHTSIO BOMBARDELLI;DZHUZEPPE MUSTIK;LUIZELLA VEROTTA |
分类号 |
C07D487/14;A61K31/12;A61K31/35;A61K31/435;A61K31/4453;A61K31/4523;A61K31/47;A61K31/4745;A61K31/475;A61K35/00;A61K36/18;A61K36/185;A61P31/12;A61P31/18;A61P31/22;A61P35/00;C07D471/12;C07D471/14;C07D487/12;(IPC1-7):C07D471/12;A61K31/645 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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