THIENOXAZINONE DERIVATIVES AS ANTIVIRAL AGENTS

摘要

Herpes protease inhibitor 4H-3,1-benzoxazin-4-one, 4H-thieno[3,2-d][1,3]oxazin-4-one, or 4H-thieno[2,3-d][1,3]oxazin-4-one derivatives which are 2-substituted by XNH-CHR1- wherein X is R4CO wherein R4 is (aryl or heteroaryl substituted by NRZOH, wherein RZ is hydrogen or C1-6alkyl)-CR6=CH- wherein R6 is hydrogen or a halo, C1-6alkyl or aryl substituent; and R1 is hydrogen or an amino acid side chain; and pharmaceutically acceptable salts thereof.