New mono- or di-substituted 2,3-benzodiazepine derivatives - are non-competitive AMPA antagonists, useful as muscle relaxants, anti-epileptics and neuroprotectors

摘要

Mono- or di-halo substituted 2,3-benzodiazepine derivatives of formula (I), their isomers and acid addition salts are new. R1, R2 = H, halogen, 1-4C alkyl, 1-4C alkoxy, nitro, CF3 or NR8R9; R3 = 1-4C alkyl, 3-5C cycloalkyl or COR13; R4, R5 = H or 1-3C alkyl; R6, R7 = H, Cl or Br, provided that not both are H at the same time; R8, R9 = H, 1-4C alkyl or COR10; R10, R13 = H, optionally substituted 1-6C alkyl, 6-10C aryl, 1-4C alkoxy, 3-5C cycloalkyl, 2-6C alkenyl, 3-5C cycloalkoxy or NR11R12; and R11, R12 = H, 1-4C alkyl, 3-5C cycloalkyl or 6-10C aryl.