摘要 |
Compounds represented by formula (I) and salts or solvates of these, each being useful especially as an acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitor, wherein (a) represents an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene, or vinylene; Ar represents optionally substituted aryl; X represents -NH-, oxygen, or sulfur; Y represents -NR1-, oxygen, sulfur, sulfoxide, or sulfone; Z represents a single bond or -NR2-; R1 and R2 each represents hydrogen, optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted lower silylalkyl; l is an integer of 0 to 15; m is 2 or 3; and n is an integer of 0 to 3.
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申请人 |
KOWA COMPANY, LTD. |
发明人 |
OZAKI, CHIYOKA;SHIBUYA, KIMIYUKI;EDANO, TOSHIYUKI;KAWAMINE, KATSUMI;SATO, YUKIHIRO;MIURA, TORU;HIRATA, MITSUTERU |