CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETICS AS beta -TURN TEMPLATES AND MODULATORS OF SH3 DOMAINS

摘要

Spirolactam compounds useful as inhibitors of protein-protein interactions modulated by SH3 domains are disclosed. Compounds of the invention are also useful as beta -turn mimetics. Also disclosed are libraries of compounds of the invention, pharmaceutical compositions of the compounds of the invention, and methods for using the compounds of the invention to inhibit growth of a cell or to inhibit protein-protein interactions modulated by SH3 domains.