PREDICTION OF INFLAMMATORY DISEASE ASSOCIATED WITH IL-1 GENELOCI POLYMORPHISMS

摘要

Methods, assays and kits are disclosed for detecting a patient's susceptibility to an inflammatory disorder such as coronary artery disease, osteoporosis, nephropathy in diabetes mellitus, alopecia areata, Graves disease, systemic lupus erythamatosus, lichen sclerosis, ulcerative colitis, diabetic retinopathy, periodontal disease, juvenile chronic arthritis particularly chronic iridocyclitis, psoriasis, insulin dependent diabetes and other diseases with an IL-1 genetic component. The methods comprise obtaining a biological sample from a patient and determining the presence or absence of a particular haplotype from the IL-1 gene cluster that is associated with an inflammatory disorder. Detection of at least one of the alleles in the haplotype indicates a susceptibility for the inflammatory disorder.