发明名称 |
CONJUGATES AND SPECIFIC IMMUNOASSAYS FOR THE METHADONE METABOLITE 2-ETHYLIDINE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE |
摘要 |
Novel chemical analogs of the methadone metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) are disclosed. The derivatives can be used for formation of EDDP-protein conjugates. The conjugates can be used in turn to raise antibodies reactive with EDDP and having a low cross-reactivity with methadone. The antibodies and EDDP-enzyme polypeptide conjugates provide the basis for specific immunoassays used in monitoring compliance with methadone treatment.
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申请公布号 |
CA2259898(A1) |
申请公布日期 |
1998.12.03 |
申请号 |
CA19972259898 |
申请日期 |
1997.09.24 |
申请人 |
MICROGENICS CORPORATION |
发明人 |
SIGLER, GERALD FRANCIS;POWELL, MICHAEL JOSEPH;COTY, WILLIAM |
分类号 |
C07D207/20;C07D207/40;C07D207/404;C07D207/416;G01N33/94;(IPC1-7):C07K16/44;A61K39/385;C07D207/452;G01N33/53;G01N33/537;G01N33/542;C12N9/96 |
主分类号 |
C07D207/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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