| 摘要 |
PROBLEM TO BE SOLVED: To screen the subject agonist or antagonist by reacting Doc2α, etc., with Munc13, etc., in the presence or absence of a candidate and subsequently selecting a candidate for increasing or decreasing the binding ability. SOLUTION: This method for screening the candidate of an agonist or antagonist of a Doc2α-Munc13 combination comprises reacting Doc2α or Doc2α analogue with Munc13 or Munc13 analogue in the presence or absence of a candidate and selecting a candidate for increasing or decreasing their binding ability. The agonist or antagonist giving an effect to the binding ability of Munc13 to Doc2α related to the release of a calcium ion-dependent neurotransmitter can thus be screened. The proteins can control the release of the neurotransmitter or hormone. |
