| 摘要 |
Disclosed are opiate peptides of general formula (I), wherein R1 is Tyr or 2',6'-dimethyltyrosine, or its analogue or derivative; R2 is D-Ala or D-Arg; R3 is Phe (p-F); R4 is Phe or Phe (p-f); X, Y and Z are hydrogen atom, their salts, derivatives and analogues, pharmaceutical compositions containing them and their use for preparation of analgesics for ache treatment. Peptides according to this invention have high degree of selectivity to u-opiate receptors. They are suitable particularly as analgesic substances with effect mainly on u-opiate receptors, they affect peripherally, and thus they avoid undesirable effects occurring in central analgesia.
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