| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new peptide having a specific amino acid sequence, having actions such as a cell proliferation-stimulating action and a cell-adhering action, and capable of being fixed to substrates to use the peptide as a medical treatment material effective for the cure, adhesion, reinforcement and regeneration stimulation of biological tissues, etc. SOLUTION: A new peptide is expressed by the formula [X is H, CH3 -C(O), CH3 -C(O)-Lys; A is Ser, Thr; D, G, L are each Ile, Val, Leu; E is Lys, Arg; J, M are each Gly, Ala; Q is Gly, Ala, Cly-Lys-Lys-Gly; Y is OH, NH2 ]. The peptide is useful as a wound-covering material, a bio-tissue adhesive, a bone- reinforcing agent, a cartilage-regenerating agent, a neurotization agent, an intractable wound-treating agent, etc. The peptide of the formula is obtained as the result of a research aiming the development of a new substance exhibiting physiological activities such as a cell proliferation-stimulating activity and a cell-adhering activity. It is found that the peptide can effectively be used for the cure of wounds, the adhesion of bio-tissues, the reinforcement of bones, the regeneration of nerves, etc. |
