ASSOCIATES OF DEPROTONATED HYALURONIC ACID, METHOD OF THEIR PREPARATION, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THESE ASSOCIATES

摘要

Associates of deprotonated hyaluronic acid with zinc or cobalt ions are prepared: in the reaction of an aqueous solution containing the zinc or cobalt salts with an aqueous solution of the hyaluronic acid salt; or by dissolving the associates of hyaluronic acid with the quaternary ammonium salt in a pair of solvents which contains an aqueous solution of zinc and cobalt ions and a solvent partially miscible with water; and consequent precipitation. Pharmaceutical and cosmetic compositions containing these associates as an active ingredient are useful for advancing the epithelization of the surface epithelial effects and promoting the skin regeneration.