| 摘要 |
PCT No. PCT/GB95/01728 Sec. 371 Date Jan. 24, 1997 Sec. 102(e) Date Jan. 24, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/03380 PCT Pub. Date Feb. 8, 1996The present invention relates to compounds of formula (I), <IMAGE> (I) wherein A is an optionally substituted phenyl naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl, thiadiazolyl having at least two adjacent ring carbon atoms or a bicyclic ring system, provided that the -CH(R3)N(R2)B-R1 and -OCH(R4-)-D linking groups arm positioned in a 1,2 relationship to one another on ring carbon atoms and the ring atom positioned ortho to the -OCHR4- linking group (and therefore in the 3-position relative to the -CHR3NR2- linking group) is not substituted; B is an optionally substituted ring system; D is an optionally substituted ring system; R1 is a variety of group as defined in the description; R2 is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenylC1-3alkyl or 5- or 6-membered heteroarylC1-3alkyl; R3 is hydrogen or C1-4alkyl; R4 is hydrogen or C1-4alkyl; and N-oxides of NR2 where chemically possible; and S-oxides of sulphur containing rings were chemically possible; and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof. Process for their preparation, intermediates in theirpreparation, their use as therapeutic agents and pharmaceutical compositions containing them.
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