发明名称 |
ICAM-1/LFA-1 short-chain peptides and method of using same |
摘要 |
Short-chain peptides replicating fragments of functional domains derived from LFA-1 and ICAM-1 parent protein sequences serve to modulate the ICAM/LFA binding interaction. In one aspect of the invention, this modulation serves to block interprotein binding reactivity, as a peptide of the invention binds to a target protein in a manner that precludes the normal binding reaction between ICAM-1 and LFA-1. In another aspect of the invention, this modulation enhances the reactivity of a first peptide, as a second peptide induces a conformational change in the target protein from a first conformation to a second, more reactive, conformation. The peptides are used according to a method including the steps of providing the proteins and applying them to a population of cells.
|
申请公布号 |
US5843885(A) |
申请公布日期 |
1998.12.01 |
申请号 |
US19970789078 |
申请日期 |
1997.02.03 |
申请人 |
THE UNIVERSITY OF KANSAS |
发明人 |
BENEDICT, STEPHEN;SIAHAAN, TERUNA J.;CHAN, MARCIA A.;TIBBETTS, SCOTT A. |
分类号 |
A61K38/00;A61P1/04;A61P3/08;A61P11/00;A61P37/00;A61P37/06;A61P37/08;A61P43/00;C07K7/06;C07K7/08;C07K14/47;C07K14/705;(IPC1-7):A61K38/02;C07K7/04;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|