Monoclonal antibodies directed against the microtubule-associated protein tau, and hybridomas secreting these antibodies

摘要

PCT No. PCT/EP93/03499 Sec. 371 Date Aug. 16, 1994 Sec. 102(e) Date Aug. 16, 1994 PCT Filed Dec. 10, 1993 PCT Pub. No. WO94/13795 PCT Pub. Date Jun. 23, 1994The invention relates to a monoclonal antibody AT 120 which forms an immunological complex with an epitope of an antigen belonging to normal human tau protein as well as abnormally phosphorylated human tau protein, with said tau protein being liable to be obtained from a brain homogenate, itself isolated from human cerebral cortex. The monoclonal antibodies of the invention can be used to detect tau and abnormally phosphorylated tau in brain extracts and in unconcentrated cerebrospinal fluid.