| 发明名称 |
Process for obtaining (+/-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine |
| 摘要 |
Process for obtaining (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine which comprises reducing ethyl (+-)-trans-4-(4-fluorophenyl)-2-piperidinone-5- carboxylate with lithium aluminium hydride or boranes to yield (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethylpiperidine, which is N-methylated with formaldehyde to yield the compound of formula I. <IMAGE>
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| 申请公布号 |
ES2121685(A1) |
申请公布日期 |
1998.12.01 |
| 申请号 |
ES19960000818 |
申请日期 |
1996.04.10 |
| 申请人 |
VITA-INVEST, S.A. |
发明人 |
DALMASES BARJOAN PERE;MARQUILLAS OLONDRIZ FRANCISCO;BOSCH ROVIRA ANNA;CARULLA OLIVER JOSE MARIA;HERBERA ESPINAL M. DE LOS REYES |
| 分类号 |
C07D211/22;C07D211/78;(IPC1-7):C07D211/22 |
主分类号 |
C07D211/22 |
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