| 摘要 |
This invention relates to a method for preparing taxane derivatives of general formula (I)by esterification at a temperature between -10 and 60° C. of a derivative of baccatine III or 10-deacetyl baccatine III of general formula (II)by means of an acid of general formula (III),followed by replacement of the protective groupings G1, G2 and R2 of the resulting product by hydrogen atoms. In formulae (I), (II) or (III), Ar stands for an aryl radical; R stands for hydrogen or acetyl; R1 is benzoyl or ter.butoxycarbonyl; G1 is a hydroxy function protective grouping, G2 stands for the acetyl radical or a hydroxy function protective grouping, and R2 stands for a hydroxy function protective grouping. |
