| 摘要 |
<p>High yield preparation of the pharmaceutical intermediate 4,4,5,5,5-pentafluoro-1-pentanol is prepared by addition of perfluoroethyl iodide to allyl alcohol using an acyl group-free radical initiator to give 4,4,5,5,5-pentafluoro-2-iodo-1-pentanol, followed by hydrogenolytic dehalogenation in the presence of a catalyst, an acid binder and a diluent. Preparation of 4,4,5,5,5-pentafluoro-1-pentanol comprises addition of perfluoroethyl iodide to allyl alcohol in the presence of an acyl group-free radical initiator, followed by hydrogenolytic dehalogenation of the resulting 4,4,5,5,5-pentafluoro-2-iodo-1-pentanol in the presence of a catalyst, an acid binder and a diluent.</p> |
