Potentiation of the immune response through delivery of compounds binding a cytoplasmic dipeptidase

摘要

A method for stimulating proliferation of T-cells containing cytoplasmic post-prolyl dipeptidase activity; the method, in one aspect, involves contacting the T-cells with an organic compound at a concentration below 10<-8>M, wherein the compound is characterized in that: (a) it is capable of crossing the membrane of T-cells to enter the cytoplasm, (b) it binds to the dipeptidase activity at a concentration of below 10<-8>M, and thus (c) stimulates proliferation of the T-cells at that concentration.