| 发明名称 |
Hemoglobin mutants with increased soluble expression and/or reduced nitric oxidescavenging |
| 摘要 |
The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin. |
| 申请公布号 |
AU7275898(A) |
申请公布日期 |
1998.11.27 |
| 申请号 |
AU19980072758 |
申请日期 |
1998.05.01 |
| 申请人 |
SOMATOGEN, INC;WILLIAM MARSH RICE UNIVERSITY |
发明人 |
MICHAEL J. WEICKERT;CHRISTOPHER B. GLASCOCK;ANTONY J MATHEWS;DOUGLAS D. LEMON;DANIEL H DOHERTY;JOHN S. OLSON |
| 分类号 |
C12N15/09;A61K38/00;C07K14/805;C12N1/21;C12N5/06;C12N15/12;C12P21/02 |
主分类号 |
C12N15/09 |
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