发明名称 |
COLLAGEN-LIKE POLYMERS WITH CELL BINDING ACTIVITY |
摘要 |
The invention is essentially directed to a biocompatible material comprising a bulk material which has covalently bound to a surface or surfaces thereof one or more biopolymer compounds, said biopolymer compounds comprising at least one peptoid residue. The biopolymer compounds are most preferably polymer compounds comprising the sequence of the formula (I): -(Gly-Pro-Nleu)(Y)-, wherein (y) denotes 9. Also disclosed is a method of binding biopolymer compounds to a bulk material, which biopolymer compounds comprise at least one peptoid residue, as well as primary amine groups, the method comprising the steps of: (a) providing aldehyde or carboxyl groups on a surface or surfaces of said bulk material; (b) reacting said primary amine groups with aldehyde or carboxyl groups to form covalent bonds.
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申请公布号 |
CA2286687(A1) |
申请公布日期 |
1998.11.26 |
申请号 |
CA19982286687 |
申请日期 |
1998.05.14 |
申请人 |
NOVARTIS AG;COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION |
发明人 |
STEELE, JOHN GERARD;GOODMAN, MURRAY;MCLEAN, KEITH MICHAEL;GRIESSER, HANS JOERG;JOHNSON, GRAHAM;BEUMER, GERRIT JAN |
分类号 |
G01N33/544;A61L27/00;A61L27/22;A61L27/34;A61L31/04;A61L31/10;C12N5/06;(IPC1-7):A61L27/00 |
主分类号 |
G01N33/544 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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