发明名称 |
PREPARATION OF TRI-IODO BENZENE COMPOUNDS |
摘要 |
The invention provides an improved process for the preparation of a compound containing a 2,4,6-triiodinated benzene ring, said process comprising reacting a 2,4,6-unsubstituted 5-amino-benzoic acid or derivative thereof with an iodine halide iodinating agent in an aqueous reaction medium, characterised in that the iodinating agent is added to an aqueous medium containing the 5-amino-benzoic acid or derivative at two different temperature ranges: (A) one or more primary portions of the agent are added at a temperature in the range 40 to 70 DEG C and then one or more secondary portions of the agent are added at a temperature in the range 75 to 95 DEG C or (B) one or more primary portions of the agent are added at a temperature in the range 75 to 95 DEG C and then one or more secondary portions of the agent are added at a temperature of 60 to 70 DEG C.
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申请公布号 |
WO9852908(A1) |
申请公布日期 |
1998.11.26 |
申请号 |
WO1998GB01488 |
申请日期 |
1998.05.22 |
申请人 |
NYCOMED IMAGING AS;SKAILES, HUMPHREY, JOHN;MALTHE-SOERENSSEN, DICK;HOMESTAD, OLE, MAGNE;STERUD, BRITT |
发明人 |
MALTHE-SOERENSSEN, DICK;HOMESTAD, OLE, MAGNE;STERUD, BRITT |
分类号 |
C07C227/16;C07C;C07C227/14;C07C229/62;C07C231/12;C07C237/46;(IPC1-7):C07C231/12 |
主分类号 |
C07C227/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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