发明名称 |
HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS |
摘要 |
The present invention relates to novel heteroarylcarboxamides which modulate the activity of protein tyrosine kinases and are expected to be useful in the treatment of abnormal protein tyrosine kinase activity driven disorders, to methods for the treatment of inappropriate FGFR activity related disorders with the heteroarylcarboxamide, N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide, and to the treatment of solid tumor cancers, especially glioblastoma and astrocytoma, with a combination of a nitrosourea, preferably BCNU (carmustin) and N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide.
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申请公布号 |
WO9852944(A1) |
申请公布日期 |
1998.11.26 |
申请号 |
WO1998US10174 |
申请日期 |
1998.05.18 |
申请人 |
SUGEN, INC. |
发明人 |
MCMAHON, GERALD;TANG, PENG, CHO;SHAWVER, LAURA, KAY;HIRTH, KLAUS, PETER |
分类号 |
C07D231/12;C07D261/18;C07D277/32;C07D401/12;C07D413/12;(IPC1-7):C07D413/02;C07D261/08 |
主分类号 |
C07D231/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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