发明名称 |
REDUCTION OF AROMATIC HALOGENIDES |
摘要 |
The invention relates to the reduction of (hetero)aromatic halogenides of general formula (I) Ar-Xn to compounds of general formula (II) Ar-Hn. To achieve this, a reduction agent is used, in particular a hydride reactant such as lithium aluminium hydride (LiAlH4) in the presence of oxygen, in particular in the form of an oxygen-inert gas mixture. Reduction in the presence of oxygen gives a good yield in short reaction times, even when working on a semiindustrial or industrial basis. Reduction using LiAlH4 in the presence of oxygen can also be used to reduce complicated heteroaromatic halogenides, for instance for reducing bromonarwedine ketone acetal to narwedine ketone acetal on an industrial scale.
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申请公布号 |
CA2289992(A1) |
申请公布日期 |
1998.11.26 |
申请号 |
CA19982289992 |
申请日期 |
1998.04.30 |
申请人 |
SANOCHEMIA PHARMAZEUTIKA AKTIENGESELLSCHAFT |
发明人 |
JORDIS, ULRICH;CZOLLNER, LASZLO;FROHLICH, JOHANNES;KUEENBURG, BERNHARD |
分类号 |
C07D491/06;C07B31/00;C07C1/26;C07C15/24;C07D333/10;C07D491/20;(IPC1-7):C07B31/00;C07D223/00;C07D307/00;C07D491/10 |
主分类号 |
C07D491/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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