发明名称 |
Process for the preparation of contrast agents |
摘要 |
The invention provides a process for the preparation of an N-alkyl-acylamino-phenyl-carboxylic acid or carboxylic acid derivative by liquid phase acylation and subsequent N-alkylation of a corresponding amino-phenyl-carboxylic acid (or carboxylic acid derivative), the improvement comprising the addition of an alkylating agent to a solution containing the reaction products of said acylation, to effect said N-alkylation.
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申请公布号 |
US5840967(A) |
申请公布日期 |
1998.11.24 |
申请号 |
US19970845134 |
申请日期 |
1997.04.21 |
申请人 |
NYCOMED IMAGING AS |
发明人 |
GULBRANDSEN, TRYGVE;INGVOLDSTAD, ODD EINAR;HOLMAAS, LARS TERJE |
分类号 |
C07C231/08;(IPC1-7):C07C229/00;C07C233/00 |
主分类号 |
C07C231/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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