发明名称 |
Cyclin dependent kinase (cdk)4 inhibitors and their use for treating cancer |
摘要 |
Certain derivatives of acridones and benzothiadiazines have been found to have anti-cancer properties by virtue of their specific inhibition of the cyclin D dependant kinase CDK4. These molecules inhibit CDK4 activity more than they inhibit the activity of other such kinases (e.g. CDC2 and CDK2). This specificity results in an improved therapeutic index when used as drugs to treat susceptible cancers. |
申请公布号 |
AU7469898(A) |
申请公布日期 |
1998.11.24 |
申请号 |
AU19980074698 |
申请日期 |
1998.04.28 |
申请人 |
THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEP |
发明人 |
MICHAEL J. KELLEY;KAZUHIKO NAKAGAWA;BARRY ROY DENT |
分类号 |
A61K31/433;A61K31/473;A61K31/549;A61P35/00;A61P43/00;C07D219/06;C07D219/08;C07D285/16;C07D285/24 |
主分类号 |
A61K31/433 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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