Phosphorylamides, their preparation and use

摘要

PCT No. PCT/JP96/02769 Sec. 371 Date Dec. 6, 1996 Sec. 102(e) Date Dec. 6, 1996 PCT Filed Sep. 25, 1996 PCT Pub. No. WO97/11705 PCT Pub. Date Apr. 3, 1997A phosphorylamide derivative represented by the general formula (I): <IMAGE> (I) wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.