Synthesis of discodermolide and analogs

摘要

A method for making discodermolide and analogs thereof. The method utilizes three precursors which correspond to three subparts of discodermolide which are formed by disconnecting the discodermolide carbon backbone at positions C-7 to C-8 and C-15 to C-16. Coupling of the precursors is accomplished using chelation-controlled alkylation.