Methods of identifying transition metal complexes that selectively cleave regulatory elements of mrna and uses thereof

摘要

Methods for selecting transition metal complexes (TMCs) that can modulate the translation of an mRNA by selectively cleaving a regulatory element of the mRNA are described. Included are in vitro, in situ, and/or in vivo methods. In addition, methods of identifying and characterizing mRNAs that contain regulatory elements which can be targeted by the TMCs of the present invention are also provided. Pharmaceutical compositions containing the TMCs of the present invention are also included.