A METHOD FOR THE PREPARATION OF TERTIARY AMINES, A COMPOUND USEFUL THEREFOR AND ALPHA-2-RECEPTOR ACTIVE TETRAHYDROISOQUINOLINE DERIVATIVES

摘要

The invention relates to a compound of formula (I) wherein Y is the fraction of a solid or soluble support, where Y may include a residue of a functional group having been attached to said support, said functional group having been hydroxy, amino, thio, epoxy or halogen, R<1> is aryl, heteroaryl, alkyl chain or ring or ring system, which may include a heteroatom, or R<1> is nothing, and R<2> is vinyl; CH2CH2X, where X is halogen; or R<3>C=CHR<4> or R<3>CH-CH2R<4>X, where R<3> and R<4> are the same or different and are alkyl, acyl, carbonyl, cyano or nitro groups and X is halogen. The invention also relates to a method for preparation of compound (I) and to its use as a substrate in the synthesis of tertiary amines. The invention still concerns a group of alpha-2-receptor active tetrahydroisoquinoline derivatives.