Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through stimulation of neutralizing antibody and cell-mediated immunity.
申请公布号
WO9834640(A3)
申请公布日期
1998.11.19
申请号
WO1998US02293
申请日期
1998.02.03
申请人
MERCK & CO., INC.;SHIVER, JOHN, W., JR.;DAVIES, MARY-ELLEN, M.;FREED, DANIEL, C.;LIU, MARGARET, A.;PERRY, HELEN, C.
发明人
SHIVER, JOHN, W., JR.;DAVIES, MARY-ELLEN, M.;FREED, DANIEL, C.;LIU, MARGARET, A.;PERRY, HELEN, C.