The invention consists of episomal expression cassettes for expression of a transgene in gene therapy. The expression cassettes consist of regulatory elements of the human cytokeratin gene and a transgene. The invention also includes liposomes for transfection of epithelial tissue with the cassettes in treatment of cystic fibrosis, emphysema, cancers of epithelial origin arising in the lung or other organs.
申请公布号
WO9851807(A1)
申请公布日期
1998.11.19
申请号
WO1998CA00478
申请日期
1998.05.14
申请人
HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP;HU, JIM;CHOW, YU-HUA;O'BRODOVICH, HUGH;TSUI, LAP-CHEE