PEPTIDES HAVING CYCLIC STRUCTURES AND EXERTING P53 PROTEIN ACTIVTY-RESTORING EFFECT ON P53 PROTEIN MUTANTS

摘要

Peptides having cyclic structures represented by the following general formula (I): R<1>(X<1>)<n1>(X<2>)<n2>(X<3>)<n3>(X<4>)<n4>(X<5>)<n5>(X<6>)<n6>(X<7>)<n7>(X<8>)<n8>(X<9>)<n9>(X<10>)<n10>(X<11>)<n11>(X<12>)<n12>(X<13>)<n13>(X<14>)<n14>(X<15>)<n15>(X<16>)<n16>(X<17>)<n17>R<2> and exerting the effect of restoring a P53 protein activity on P53 protein mutants or pharmacologically acceptable salts thereof. In said formula (I) X<i> means an arbitrary member selected from among X<1> to X<17> while n<i> means an arbitrary member selected from among n<1> to n<17> (provided that i is an integer of from 1 to 17), then X<i> represents an amino acid residue or an organic acid residue; a functional group in a residue X<p> selected among X<1> to X<11> (provided that p is an integer of from 1 to 11) and a functional group X<q> selected from among X<8> to X<17> (provided that q is an integer of from 8 to 17 and larger than p) form a cyclic structure having a crosslinkage selected from among S-S, S-CH2-S, S-CH2-C6H4-CH2-S, S-CH2-CO, CO-NH, NH-CO, O-CO or CO-O; R<1> represents optionally substituted alkanoyl, etc.; and R<2> represents optionally substitued alkoxy, etc.