| 摘要 |
<p>The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with -H, -Et, and/or -OH and the ethyl side-chain has been substituted with hydroxymethyl or dihydroxyxyclohexylmethyl side-chains. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.</p> |
