| 摘要 |
PURPOSE:To enable quantitative production of the subject ester by carrying out the asymmetric reduction of a 2-ketopantothenic acid ester with a microorganism having reducing power and belonging to genus Kluyveromyces, Hansenula, Sporobolomyces, etc. CONSTITUTION:At least one kind of microorganism having reducing power and selected from the group of microorganisms of genus Aerobacter, Erwinia, Agrobacterium, Corynebacterium, Arthrobacter, Xanthomonas, Kluyveromyces, Saccharomyces, Hansenula, Sporobolomyces, Candida, Rhodotorula, Pichia and Mortierella is aerobically cultured in a liquid medium. The obtained culture product, microbial cell separated from the culture liquid, etc., are made to react at 10-50 deg.C with a new 2'-ketopantothenic acid ester derived from ketopantolactone and a beta-alanine ester. A D-pantothenic acid ester can be quantitatively produced by this process. |
