The invention provides a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme for use as a medicament in a mammalian host wherein the gene construct is capable of expressing the cell targeting moiety and enzyme as a conjugate within a target cell in the mammalian host and wherein the conjugate is directed to leave the cell thereafter for selective localisation at a cell surface antigen recognised by the cell targeting moiety.
申请公布号
WO9851787(A2)
申请公布日期
1998.11.19
申请号
WO1998GB01294
申请日期
1998.05.05
申请人
ZENECA LIMITED;EMERY, STEPHEN, CHARLES;BLAKEY, DAVID, CHARLES