Basically substituted triazolidines, processes for their manufacture and pharmaceutical preparations containing them

摘要

The invention comprises compounds of the general formula (wherein R represents a phenyl group which may be substituted by at least one substituent selected from halogen atoms, the trifluoromethyl group and alkyl and alkoxy groups containing 1 to 4 carbon atoms, R1 represents an alkyl group containing 1 to 4 carbon atoms or an aralkyl group in which the alkylene residue contains 1 or 2 carbon atoms, R2 and R3 each represents an alkyl group containing 1 to 4 carbon atoms or a cycloalkyl group containing 5 to 7 carbon atoms, or together with the adjoining nitrogen atom are members of a ring system containing 4 or 5 carbon atoms and which may contain as a further hetero atom an oxygen, nitrogen or sulphur atom and/or at least one substituent, and A represents an alkylene group containing 2 to 4 carbon atoms) and physiologically tolerable acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by standard methods from a compound of the formula or an appropriate 4-substituted derivative thereof. Starting materials in which R=phenyl, R1= methyl and the 4-substituent is -CH2CH2Br, -CH2CH2CN or -CH2CH(OC2H5)2 are prepared from (II, R=phenyl, R1=methyl. The compounds of the invention are sedatives, and may be administered orally or parenterally in the form of pharmaceutical preparations (e.g. tablets and dragees) containing them together with a carrier.