发明名称 |
Process for preparing optically active 4-hydroxy-2-pyrrolidone |
摘要 |
A process for preparing optically active 4-hydroxy-2-pyrrolidone comprising asymmetrically hydrogenating an N-substituted-4-amino-3-oxobutanoic ester represented by formula (I): <IMAGE> (I) wherein R1 represents a benzyloxycarbonyl group, the benzene ring of which may be substituted; and R2 represents a lower alkyl group having 1 to 4 carbon atoms, in the presence of a ruthenium-optically active phosphine complex as a catalyst to obtain an optically active N-substituted-4-amino-3-hydroxybutanoic ester, deblocking, and cyclizing the ester. A series of the reactions can be carried out in one pot. Optically active 4-hydroxy-2-pyrrolidone is obtained in high yield with high optical purity, and is useful in the synthesis of carbapenem antibiotics
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申请公布号 |
US5837877(A) |
申请公布日期 |
1998.11.17 |
申请号 |
US19970790931 |
申请日期 |
1997.01.29 |
申请人 |
TAKASAGO INTERNATIONAL CORPORATION |
发明人 |
MITSUHASHI, SHIGERU;KUMOBAYASHI, HIDENORI |
分类号 |
B01J31/24;C07B53/00;C07B61/00;C07D207/26;C07D207/273;(IPC1-7):C07D207/273 |
主分类号 |
B01J31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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