Imidazole-derivatives having agonistic or antagonistic activity on the histamine H3-receptor

摘要

<IMAGE> (a) The invention relates to imidazole-derivatives of general formula (a). The invention in particular relates to derivatives having agonistic or antagonistic activity on the histamine H3-receptor. The novel imidazole-derivatives are isothio urea-, guanidine- and amidine-derivatives. The invention further relates to pharmaceutical compositions comprising the novel imidazole-derivatives as well as to methods for preparing the derivatives and for preparing pharmaceutical compositions having antagonistic and agonistic activity on the histamine 3 receptor.