发明名称 |
Ocular microsphere delivery system |
摘要 |
A sustained release drug delivery composition and a method of making same are provided which comprises microspheres containing a pharmaceutically active agent, a core of a ion-exchange resin and a polymeric coating completely surrounding the core wherein the coating is water-insoluble and hydrolytically stable in physiological environments. The coating is non-erodible in physiological environments and is characterized by a diffusion constant suitable for the pharmaceutical agent to diffuse from the core to an aqueous environment at a predetermined release rate.
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申请公布号 |
US5837226(A) |
申请公布日期 |
1998.11.17 |
申请号 |
US19950530949 |
申请日期 |
1995.09.19 |
申请人 |
VITAPHORE CORPORATION C/O INTEGRA LIFESCIENCES CORP. |
发明人 |
JUNGHERR, LISA B.;OTTOBONI, THOMAS B. |
分类号 |
A61K9/52;A61K9/00;A61K9/16;A61K47/48;(IPC1-7):A61K9/50 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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