Bovine beta -mannosidase nucleic acid sequence

摘要

The gene encoding bovine beta -mannosidase has been identified, cloned, sequenced and characterized. The full-length cDNA contains 3852 nucleotides encoding 879 amino acids. The mutation involved in bovine beta -mannosidosis has also been identified. Oligonucleotides and antibodies raised to the gene product are provided and are used in a variety of methods including assays to screen for an abnormal beta -mannosidase gene and diagnosis of beta -mannosidosis.