2-benzoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide derivatives and their useas inhibitors of hepatic production of apob-100

摘要

The present invention relates to a compound of formula (I), wherein R<0> représents hydrogen, halogen, C1-4alkyl, C1-4alkoxy or a methylenedioxy group, and n represents an integer from 1-4; R<1> represents hydrogen, halogen, C1-4alkyl, C1-4alkoxy, trifluoromethoxy or a methylenedioxy group, and p represents an integer from 1-4; R<2> represents one or more groups selected from hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, a methylenedioxy group, NR<4>R<5>, -(C1-4alkylene)-NR<6>R<7>, -NR<4>- or -O-(C1-4 alkylene)-NR<8>R<9>, 4-morpholino, or formula (II), and m represents an integer from 1-4; R<3> represents hydrogen or C1-4 alkyl; R<4>-R10 independently represent hydrogen or C1-4 alkyl; or a pharmaceutically acceptable salt or solvate thereof, to processes for their preparation; and their use in the treatment of conditions mediated by ApoB-100 regulation.