VERWENDUNG VON HALOGENIERTEN BETA-LACTAMEN ZUR HERSTELLUNG VON 3-HYDROXYCEPHEM-DERIVATEN

摘要

A halogenated beta -lactam compound represented by general formula (III), wherein Ar represents optionally substituted aryl; R<1> represents optionally protected amino; R<2> represents hydrogen or a carboxyl blocking group; R<3> represents hydrogen or a hydroxyl blocking group; and X represents halogen. A process for producing a 3-hydroxycephem derivative is represented by general formula (I) in an industrially advantageous manner by reducing the compound (III) either with a metallic reducing agent or electrolytically. In formula (I), R<1>, R<2> and R<3> are as defined above.