| 发明名称 |
METHODS OF MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION WITH QUINAZOLINE-BASED COMPOUNDS |
| 摘要 |
The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with quinazoline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to quinazoline compounds and pharmaceutical compositions comprising these compounds.
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| 申请公布号 |
CA2288778(A1) |
申请公布日期 |
1998.11.12 |
| 申请号 |
CA19982288778 |
申请日期 |
1998.05.01 |
| 申请人 |
SUGEN, INC. |
发明人 |
KUTSCHER, BERNHARD;WEINBERGER, HEINZ;MCMAHON, GERALD;TANG, PENG C.;APP, HARALD |
| 分类号 |
A61K31/517;A61P35/00;A61P43/00;C07D239/84;C07D239/94;C07D239/95;C07D403/04;G01N33/573;G01N33/574;(IPC1-7):C07D239/84;C07D401/12;C07D403/12;C07D405/12;C07D409/12;G01N33/50;A61K31/505 |
主分类号 |
A61K31/517 |
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