发明名称 |
SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS |
摘要 |
A compound of formula (I) wherein R<1> is hydrogen, halogen or CN or a group CF3, OCF3, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, C2-4alkenyloxy or C2-4alkynyloxy, each of which groups is unsubstituted or substituted with one or two halogen atoms or with a pyridyl or phenyl ring each of which rings may be unsubstituted or independently substituted by one or two halogen atoms or nitro, cyano, amino, methyl or CF3 groups; R<2> is hydrogen, halogen or CN or a group CF3, OCF3, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, C2-4alkenyloxy or C2-4alkynyloxy each of which groups is unsubstituted or substituted with one or two halogen atoms; L is O, S, or NR<n> where R<n> is H, C1-6alkyl or C3-6cycloalkyl; X is a five or six-membered optionally substituted heterocycle; Y is optionally branched C1-4alkylidene optionally substituted by an oxo group or Y is a group (CH2)jO wherein the oxygen atom is nearest the group X and j is 2, 3 or 4; Z is a five or six-membered optionally substituted heterocycle; or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising it, its use in medical treatment, processes for producing it and intermediates used in those processes are disclosed.
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申请公布号 |
WO9850385(A1) |
申请公布日期 |
1998.11.12 |
申请号 |
WO1998GB01307 |
申请日期 |
1998.05.06 |
申请人 |
MERCK SHARP & DOHME LIMITED;CARLING, WILLIAM, ROBERT;LADDUWAHETTY, TAMARA;MACLEOD, ANGUS, MURRAY;MERCHANT, KEVIN, JOHN;MOORE, KEVIN, WILLIAM;STERNFELD, FRANCINE;STREET, LESLIE, JOSEPH |
发明人 |
CARLING, WILLIAM, ROBERT;LADDUWAHETTY, TAMARA;MACLEOD, ANGUS, MURRAY;MERCHANT, KEVIN, JOHN;MOORE, KEVIN, WILLIAM;STERNFELD, FRANCINE;STREET, LESLIE, JOSEPH |
分类号 |
A61K31/5025;A61P25/28;A61P43/00;C07D487/04;(IPC1-7):C07D487/04;A61K31/50 |
主分类号 |
A61K31/5025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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